Hepatoprotective and neuroprotective effect of polyprenols
It is known that, in hepatosis, not only liver is affected by toxins, but also all the internal organs and the central nervous system. Subacute hepatosis was modelled in rats in laboratory conditions, followed by treatment with polyprenols in different doses. Blood and liver indicators improved in the animals, a psycho-activating effect on the brain was observed, as well as other positive effects. As a result, it was concluded that polyprenols have a pronounced hepatoprotective and neuroprotective effect in the wide range of doses.
Polyprenols and Alzheimer (preclinical studies)
The study was conducted in rats in the conditions of the experimentally created model of dementia of the Alzheimer type. When a polyprenolic preparation was introduced, the animals completely restored the disordered capacity for the non-spatial and spatial types of learning. As a result, it was concluded that it was possible to clinically study the action of polyprenolic preparations with the purpose of their further use in the therapy of cognitive disorders, dementias of different genesis, including those of the Alzheimer type.
Polyprenols and Alzheimer (clinical studies)
The study was conducted in St. Petersburg in I.I. Skvortsov-Stepanov Psychiatric Hospital No. 3. The study included 25 persons in the age of 54 to 78 years with Alzheimer's disease, who were given polyprenols during 3-4 months. In 40% of patients had an expressed improvement in cognitive functions by all the indicators. The disease passed from a severe form to a milder one in 48%. Improvement in the neurological status were in 25% of patients, and the parkinsonian syndrome on the average decreased by 5 points on the scale of parkinsonism within 1 month, which is a good prognostic factor in the treatment of this disease.
Polyprenols and craniocerebral injury
Craniocerebral injury is one of the most common types of injuries, which significantly reduces the ability to work and can lead to disability. The consequences are usually treated with medications. The study examined the effectiveness of treatment of craniocerebral injuries (CCI) with polyprenols in rats. As a result, the damaged brain tissues restored, biochemical blood indices and work of the cardio-vascular system normalized, and behavior improved in rats. The conclusion is that polyprenols have pronounced neuroprotective activity and restore functional activity of the brain after a craniocerebral injury.
Polyprenols and neurotransmitter systems in the brain (preclinical studies)
The study was conducted in laboratory conditions. It is known that when hepatic encephalopathy occurs, not only liver cells but also brain cells are damaged. The study examined the activity of different parts of the brain in rats with experimental hepatic encephalopathy after the introduction of the polyprenolic preparation.