Hepatoprotective properties of polyprenols

Clinical study

Hepatoprotective properties of polyprenols were studied in several clinical centers. The study involved 120 patients with various hepatic injuries, which took polyprenols within 3 months. Improvements of blood indicators, increase of activity of the antioxidant system, normalization of liver functions were observed in the patients. The conclusion is that polyprenols are recommended as an active hepatoprotector in chronic injury of the hepatobiliary system of different etiology.

Solagran Limited, Melbourne, Australia
S.M. Kirov Academy of Forestry Engineering in Saint Petersburg, Saint Petersburg, Russia
SPb MALO, Saint Petersburg, Russia

Study Purpose

Evaluation of the efficacy and safety of polyprenols* in comparison with the preparation of Essentiale Forte in patients with various forms of pathology of the hepatobiliary system, including hepatic injuries of alcoholic etiology.

Materials and Methods

A double blind placebo-controlled clinical study of the polyprenolic preparation* was conducted in 120 patients in 4 clinical centers: Medical Academy of Postgraduate Education of the Ministry of Health of the Russian Federation, S.P. Botkin Hospital, Saint Great Martyr George Hospital, the AIDS Center. The criteria of efficiency of the preparation were the degree of manifestation of the main clinical symptoms, disease dynamics, restoration of the liver function on the basis of the data of biochemical and clinical blood tests. The biochemical blood test included: indicators of protein metabolism, ALT, AST, ALP, gamma-glutamatetransferase (GGT), dynamics of changes in total cholesterol and blood lipid spectrum, a study of the function of the urinary system, blood sugar, prothrombin time, indices of antioxidant activity. All the indicators were assessed before treatment, during treatment and after a three-month course of treatment.


The new plant polyprenolic preparation* is a concentrate of polyprenols extracted from the needles of pine (Pinus silvestris) and spruce (Picea abies). The pharmacological action of prenols is based on the substitutive effect in cases of deficit of dolichol and insufficiency of the dolichol phosphate cycle that occurs in cases of chronic inflammatory-degenerative liver diseases, oncological diseases, dysmetabolic syndrome.

A randomized double blind study confirmed the hepatoprotective action of polyprenols* and the safety of their use in cases of chronic liver diseases and metabolic syndrome. The preparation shows a wide range of biological properties: the fastest recovery to normal activity of blood plasma enzymes that characterize the function of hepatocytes. A pronounced positive dynamics of the microsomal enzyme of GGT in patients abusing alcohol is observed. As a result of the therapy, there is normalization of the blood lipid spectrum (increase of antiatherogenic lipoproteids, decrease of atherogenicity factor) and carbohydrate metabolism, the level of activity of the antioxidant system significantly increases – by 175% by the 8th week of the therapy. The effect of the treatment with polyprenols* occurs on average 2 weeks earlier than that of the famous preparation of Essentiale Forte. The polyprenolic preparation* has recommended itself as an effective and safe medication (there were no side effects during treatment).


Polyprenols* are recommended as an active hepatoprotector in cases of chronic injury of the hepatobiliary system of different etiology. (Published in the journal of "Gastroenterology in Saint Petersburg", No. 1-2, 2007, P. Ml06)

* A polyprenolic preparation of Ropren was used the study, which is a pure concentrate of polyprenols (the total fraction is 95%). The text of the study is provided by courtesy of Solagran.